Probing osmolyte participation in the unfolding transition state of a protein
نویسندگان
چکیده
منابع مشابه
Retraction for Dougan et al., Probing osmolyte participation in the unfolding transition state of a protein.
Understanding the molecular mechanisms of osmolyte protection in protein stability has proved to be challenging. In particular, little is known about the role of osmolytes in the structure of the unfolding transition state of a protein, the main determinant of its dynamics. We have developed an experimental protocol to directly probe the transition state of a protein in a range of osmolyte envi...
متن کاملProbing osmolyte participation in the unfolding transition state of a protein
CHEMISTRY Retraction for “Probing osmolyte participation in the unfolding transition state of a protein,” by Lorna Dougan, Georgi Z. Genchev, Hui Lu, and Julio M. Fernandez, which appeared in issue 24, June 14, 2011, of Proc Natl Acad Sci USA (108:9759– 9764; first published May 25, 2011; 10.1073/pnas.1101934108). The authors note the following: “We wish to retract our article because interpret...
متن کاملProbing the Folding-Unfolding Transition of a Thermophilic Protein, MTH1880
The folding mechanism of typical proteins has been studied widely, while our understanding of the origin of the high stability of thermophilic proteins is still elusive. Of particular interest is how an atypical thermophilic protein with a novel fold maintains its structure and stability under extreme conditions. Folding-unfolding transitions of MTH1880, a thermophilic protein from Methanobacte...
متن کاملPredicting the energetics of osmolyte-induced protein folding/unfolding.
A primary thermodynamic goal in protein biochemistry is to attain predictive understanding of the detailed energetic changes that are responsible for folding/unfolding. Through use of recently determined free energies of side-chain and backbone transfer from water to osmolytes and Tanford's transfer model, we demonstrate that the long-sought goal of predicting solvent-dependent cooperative prot...
متن کاملcritical period effects in foreign language learning:the influence of maturational state on the acquisition of reading,writing, and grammar in english as a foreign language
since the 1960s the age effects on learning both first and second language have been explored by many linguists and applied linguists (e.g lennerberg, 1967; schachter, 1996; long, 1990) and the existence of critical period for language acquisition was found to be a common ground of all these studies. in spite of some common findings, some issues about the impacts of age on acquiring a second or...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1101934108